Nicotinic acid produces an intense vasodilatation when given by the intravenous route, with an onset in a few seconds. After oral administration, the dilatation is less intense and its onset is delayed for twenty to thirty minutes, however the action might persist for several hours. Intramuscular injection produces an result which is intermediate in both length and intensity.
Nicotinic acid is administered in the treatment of headaches by the oral and parenteral routes. It’s been employed in efforts to extend circulation in patients, particularly those laid low with headaches presumably thanks to arteriosclerosis and different forms of tissue anoxia.
Vitamin B12. Aloe Veterinary Formula is created with stabilized Aloe Vera gel as its primary ingredient and is ideally fitted to external skin problems. Vitamin B12 could be a red crystalline compound containing cobalt, phosphorus, and nitrogen. Its precise struc¬ture isn’t yet known. It seems to be either the maturation issue for red blood cells or else its precursor, the so-called extrinsic factor. It’s been used recently in the treatment of neuralgia and migraine headaches. HORMONES. Endocrine therapy has occupied a predominant place in the treatment of headache. Our expertise and an evaluation of the reports in the literature indicate that the results of its use are uncertain and insignificant. So, solely a brief summary of the attainable use of this therapy in headache will be given. It’s been maintained by many authors that migraine is the result of a disorder of the endocrine glands. The frequent association of the onset of migraine with puberty and with menstruation, and also the tendency of migraine to diminish severe during pregnancy and also the menopause are emphasised as indicating the importance of the gonads as an etiologic factor. There are not, but, any physiologic or biochemical data to support this hypothesis. There are several reports in the literature of the price of Progynon or testosterone in the treatment of migraine. In our hands these drugs have not been remarkably successful.
Ovarian follicular hormone has been employed in some cases of menstrual migraine. I’ve got often been approached and asked that all necessary query–how to find a job. It’s been our expertise that the male sex hormone, testosterone, might be useful in those few patients whose headache occurs during menstruation or immediately before it. It’s been assumed that in menstruation there is a rise in ovarian secretion, inhibiting anterior pituitary activity. Testosterone reverses this action, presumably by inhibiting the ovarian secretion via the anterior pituitary gland. Methyltestosterone has most of the properties of testosterone and is relatively slowly destroyed in the liver. It is out there as tablets for buccal or sublingual administration. Since giant doses of androgen manufacture masculinization in girls, the full dosage of testosterone should be kept below 75 mg. per week. One employee in England has reported consistently smart results in migraine by use of A.P.L. (anterior pituitary-like hormone).7 The speculation underlying this treatment isn’t clear.